DR. AREN NILSSON
You Don’t Have a Willpower Problem. You Have a Mitochondrial Problem.
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PerformanceNovember 2025·12 min read

You Don’t Have a Willpower Problem. You Have a Mitochondrial Problem.

The Lie You Keep Telling Yourself

Every morning you wake up tired. You hit snooze three times. You drag yourself through the day running on caffeine and whatever residual momentum you can manufacture. By 2 PM, your brain is soup. By 7 PM, the workout you planned feels impossible. By 9 PM, you're on the couch wondering where your ambition went.

And what do you tell yourself? "I need more discipline." "I need to want it more." "I'm just not motivated enough."

You're wrong. Not about the symptoms. Those are real. You're wrong about the diagnosis.

You don't have a willpower problem. You have an energy production problem. Your mitochondria, the organelles inside every cell that produce ATP (the energy currency your body runs on), are not functioning the way they should. And until you fix that, no amount of motivational podcasts, morning routines, or cold plunges is going to change the fundamental equation.

You can't output energy you don't produce.

The Missing Variable

The entire personal development industry is built on a flawed assumption: that performance is primarily a function of mindset, habits, and discipline. Don't get me wrong, those things matter. But they're software. Your mitochondria are the hardware.

If your laptop has a failing battery, you can install all the productivity apps you want. It's still going to die at 30%.

The same principle applies to your body. Mitochondria produce ATP through oxidative phosphorylation. This process requires substrates (from food), oxygen (from your cardiovascular system), and a functioning electron transport chain (which requires specific cofactors and nutrients). When any part of this system is compromised, your cells produce less energy. Period.

And here's what most people don't realize: your brain is the most metabolically demanding organ in your body. It represents about 2% of your body weight but consumes roughly 20% of your total energy output. When mitochondrial function declines, cognitive performance is the first thing to go. Focus, decision-making, willpower, emotional regulation: these are all energy-expensive processes.

That afternoon brain fog? That's not a character flaw. It's a bioenergetic deficit.

How I Know This Works

During chiropractic school, I put this theory to the test in the most extreme way possible. Not on purpose. Just by the nature of what my life demanded.

Here was my daily reality: 100-mile round-trip commute. Full-time doctoral program with one of the most demanding curricula in healthcare education. New father. Not once, not twice, but three times during my time in school. My wife and I had three children while I was getting my degree.

I was sleeping 5 to 6 hours a night. Not by choice. By necessity.

And I maintained my physique. Trained consistently. Graduated Cum Laude. Didn't lose my mind, my marriage, or my health.

I'm not saying this to flex. I'm saying it because the "discipline and willpower" explanation doesn't account for it. I wasn't more disciplined than the classmates who burned out. I wasn't mentally tougher. I was strategically supporting my cellular energy production so that the energy demands of my life didn't exceed my body's capacity to meet them.

Here's what that actually looked like.

The Mitochondrial Support Stack

Before I break this down, a disclaimer: I'm a doctor. I'm writing about what I used and what the research supports. This is not medical advice. Work with a qualified provider before implementing any protocol. Now let's get into it.

Coenzyme Q10 (CoQ10)

CoQ10 is not optional for mitochondrial function. It is a direct participant in the electron transport chain, specifically shuttling electrons between Complex I/II and Complex III. Without adequate CoQ10, the rate-limiting step in ATP production is compromised.

Your body produces CoQ10 endogenously, but production declines with age (starting in your mid-20s), and it's depleted by statin medications, chronic stress, and high metabolic demand. If you're training hard, sleeping little, and running at high output, your CoQ10 demand likely exceeds your production.

I use the ubiquinol form (reduced CoQ10) because it's more bioavailable than ubiquinone. The research supports doses of 100-300mg daily for mitochondrial support. You'll typically notice the effects within 2-3 weeks: more sustained energy, better exercise recovery, and improved mental clarity.

NAD+ Precursors

Nicotinamide adenine dinucleotide. If CoQ10 is the shuttle in the electron transport chain, NAD+ is the currency exchange. It's involved in over 500 enzymatic reactions, including every major step of cellular energy metabolism. It's also critical for DNA repair and sirtuin activation (the longevity pathways everyone talks about).

NAD+ levels decline with age. Significantly. A 50-year-old has roughly half the NAD+ of a 20-year-old. This decline correlates directly with the fatigue, cognitive decline, and reduced recovery capacity that people attribute to "just getting older."

Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are the two primary precursors that can raise NAD+ levels. I use NMN because the research on direct NAD+ elevation is slightly more robust, but both work. The key is consistency: NAD+ precursors need to be taken daily, as NAD+ turnover is rapid.

Creatine

Yes, the bodybuilding supplement. Except it's not just a bodybuilding supplement. It's one of the most well-researched compounds in all of sports nutrition, and its benefits extend far beyond the gym.

Creatine functions as a phosphate shuttle in the phosphocreatine system, which provides rapid ATP regeneration. Think of it as your cellular turbocharger for high-demand situations. When you need quick energy (sprinting, heavy lifting, intense cognitive work), the phosphocreatine system bridges the gap until oxidative phosphorylation can catch up.

The brain research on creatine is particularly compelling. Studies show that creatine supplementation improves working memory, reduces mental fatigue, and enhances cognitive performance under stress and sleep deprivation. During those 5-hour sleep nights in chiropractic school, creatine wasn't optional. It was essential.

5 grams daily. Every day. No loading phase needed. No cycling. Just consistent daily supplementation. It's cheap, it's safe, and it works.

Methylene Blue

This is the one that raises eyebrows, so let me be clear about what it is and what it isn't.

Methylene blue is not a supplement in the traditional sense. It's a pharmaceutical compound that has been used in medicine for over a century, primarily as a treatment for methemoglobinemia. What makes it relevant to mitochondrial function is its ability to act as an alternative electron carrier in the electron transport chain.

Here's why that matters. When Complex I or Complex III are dysfunctional (which happens with aging, oxidative stress, and toxic exposure), electrons can leak and form reactive oxygen species instead of contributing to ATP production. Methylene blue can accept electrons and shuttle them directly to Complex IV, bypassing the damaged complexes. It's essentially a detour around a traffic jam in your electron transport chain.

The cognitive effects are noticeable. At low doses (0.5-1mg/kg), methylene blue crosses the blood-brain barrier and enhances mitochondrial function in neurons. Users consistently report improved focus, mental clarity, and sustained attention.

The caveats are important. Methylene blue interacts with serotonergic medications (including SSRIs) and should never be combined with them due to serotonin syndrome risk. It will turn your urine blue-green, which is harmless but alarming if you're not expecting it. And dose matters enormously: the mitochondrial benefits occur at LOW doses. High doses have the opposite effect.

This is not something to experiment with casually. Work with a provider who understands it.

Beyond Supplements: The Foundation

Supplements are tools. They're not substitutes for the basics. If your foundation is garbage, no stack in the world will save you.

Sleep quality over quantity. I was getting 5-6 hours, but I optimized every minute. Cool room, blackout curtains, no screens 30 minutes before bed, magnesium glycinate. When you can't get more sleep, you have to get better sleep.

Strategic nutrition. Your mitochondria need substrates. That means adequate protein (amino acids for mitochondrial biogenesis), healthy fats (your mitochondrial membranes are lipid bilayers), and micronutrients (B vitamins, iron, magnesium, copper). I ate to fuel performance, not to fit a diet trend.

Training as medicine. Exercise is the single most powerful stimulus for mitochondrial biogenesis. Nothing else comes close. Resistance training and high-intensity interval work both signal your body to produce more mitochondria and improve the function of existing ones. I trained even on 5 hours of sleep because the long-term energetic payoff exceeded the short-term cost.

Stress management. Chronic cortisol elevation directly impairs mitochondrial function. It increases oxidative stress, reduces membrane potential, and accelerates mitochondrial aging. I couldn't eliminate stress from my life, but I could modulate my response to it through breathwork, structured recovery, and ruthless prioritization of what actually mattered.

The Real Performance Conversation

I'm tired of the "just work harder" narrative. Not because hard work doesn't matter. It does. But because it's incomplete to the point of being misleading.

When you tell someone who is mitochondrially compromised to "just push through," you're asking them to run a race with a flat tire. They might still finish. But they'll damage the wheel in the process. And the next race will be even harder.

The people who seem to have limitless energy aren't superhuman. They're not more disciplined than you. They have better cellular energy production. Either through genetics, through habits that support mitochondrial function, or through targeted interventions that optimize their bioenergetics.

Once I understood this, everything changed. I stopped trying to manufacture energy through sheer force of will and started creating the conditions for my body to produce it naturally. The discipline, the motivation, the drive: those came back as a byproduct of having the energy to express them.

You don't need another productivity system. You need to charge your biological battery.

Where to Start

If this resonates with you, here's a practical starting point:

Step 1: Get tested. Organic acids testing can give you direct insight into mitochondrial function. Markers like citric acid cycle intermediates, CoQ10 levels, and markers of oxidative stress will tell you where the bottlenecks are. Don't guess. Measure.

Step 2: Fix the foundation. Before you add any supplements, audit your sleep, nutrition, training, and stress. These are non-negotiable. If you're sleeping 4 hours, eating garbage, never exercising, and stressed to the gills, no supplement will overcome that.

Step 3: Targeted supplementation. Based on your testing and your provider's guidance, implement targeted support. CoQ10, NAD+ precursors, creatine, and the other interventions I discussed are starting points, not prescriptions. Your specific needs may differ.

Step 4: Reassess. Retest in 3-6 months. Measure the change. Adjust accordingly. This is how medicine should work: test, intervene, measure, refine.

The body is not a black box. It's a system. And like any system, when you understand the inputs, you can optimize the outputs.

Stop blaming your willpower. Start charging your cells.

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I write about root-cause medicine, biohacking, performance, and the things I wish someone had told me 15 years ago. No spam. No fluff. Just signal.